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Nucleic acid modification reagent Product List

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Service Introduction: "Custom Oligonucleotide Synthesis Service"

Total support from basic research to clinical development! We provide oligonucleotides with optimal specifications.

At Ajinomoto Bio-Pharma Services Gene Design, we provide a variety of nucleic acid drug seeds such as siRNA, aptamers, antisense, decoys, miRNA, and CpG-ODN, tailored to optimal specifications for cell assays, in vivo experiments, in vitro diagnostic pharmaceuticals, and clinical trial GMP-compliant products. We also offer fluorescent labeling, such as Alexa modifications, and detection probes like LNA oligos at reasonable prices to support your basic research. 【Features】 - Extensive experience with cross-linked nucleic acids such as LNA and BNA, various modifications like 2’-OMe RNA and 2’-F RNA, and peptide, PEG, and ligand terminal additions. - Process development and analytical method development with an eye toward scale-up. - Experience in examining and validating standard testing methods. - Conducting stability tests necessary for GLP studies and clinical development. For more details, please contact us or download the catalog.

  • Other contract services
  • Contract manufacturing
  • Nucleic acid modification reagent

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4'-Thioribonucleoside phosphoramidite

Advantages of 4'-thioribonucleoside phosphoramidites!

"Three Innovations Brought by 4'-Thio Modification" 1. Excellent Nuclease Resistance (Approximately 600 Times Higher than Natural) 4'-thioRNA has a structure in which the oxygen at the 4' position of the ribose ring is replaced by sulfur. This slight change creates stability. 2. Strong and Accurate Hybridization Ability In addition to stability, the binding strength to the target (Tm) is also enhanced, which is a strength of 4'-thio. - Increase in Tm: An increase of approximately 1°C in Tm is expected per modification, providing a stabilization effect comparable to that of 2'-O-methyl modifications. - Maintenance of A-type Structure: By inducing the sugar moiety into an RNA-like "C3'-endo conformation," it improves thermal stability while maintaining a structure close to natural RNA. 3. Compatible with Existing Platforms Despite being a new technology, its low introduction cost is a significant advantage. - Standard Synthesis Method: Supplied in DMTr-protected and phosphoramidite form, it can be used directly with your existing automated synthesizers. - Smooth Transition: Base protection uses standard methods (such as Bz, iBu), allowing the deprotection and purification processes to be optimized based on existing protocols.

  • Custom reactions and synthesis
  • Nucleic acid modification reagent

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